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Name Phospho-BLNK (Tyr96) Polyclonal Antibody
Catalog# A340349
Type Primary Antibody
Reactivity Human, Mouse, Monkey
Application WB, IHC, ELISA
Host Rabbit
Clonality Polyclonal
Conjugate Non-conjugated
Description Functions as a central linker protein that bridges kinases associated with the B-cell receptor (BCR) with a multitude of signaling pathways, regulating biological outcomes of B-cell function and development. Plays a role in the activation of ERK/EPHB2, MAP kinase p38 and JNK. Modulates AP1 activation. Important for the activation of NF-kappa-B and NFAT. Plays an important role in BCR-mediated PLCG1 and PLCG2 activation and Ca(2+) mobilization and is required for trafficking of the BCR to late endosomes. However, does not seem to be required for pre-BCR-mediated activation of MAP kinase and phosphatidyl-inositol 3 (PI3) kinase signaling. May be required for the RAC1-JNK pathway. Plays a critical role in orchestrating the pro-B cell to pre-B cell transition (By similarity). Plays an important role in BCR-induced B-cell apoptosis.
Uniprot Q8WV28
Isotype IgG
Immunogen Synthesized peptide derived from human BLNK around the phosphorylation site of Y96.
Storage buffer PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH7.3
Storage instruction Store at -20℃. Avoid freeze / thaw cycles.
Alias AGM4,B cell adapter containing SH2 domain protein,B cell adapter containing Src homology 2 domain protein,B cell adaptor containing SH2 domain,B cell linker,B cell linker protein,B cell-specific adaptor protein,B-cell activation,B-cell adapter containing a SH2 domain protein,B-cell adapter containing a Src homology 2 domain protein,B-cell linker protein,BASH,Bca,BLNK,BLNK s,BLNK,Cytoplasmic adapter protein,Ly 57,Ly57,Lymphocyte antigen 57,Lyw 57,Lyw57,MGC111051,SH2 domain-containing leukocyte protein,65-KD,SLP 65,SLP-65,SLP65,Src homology [SH2] domain-containing leukocyte protein of 65 kD,Src homology 2 domain containing leukocyte protein of 65 kDa,Src homology 2 domain-containing leukocyte protein of 65 kDa
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