KEAP1 Polyclonal Antibody
- Catalog Number : A340714
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Introduction
Retains NFE2L2/NRF2 in the cytosol. Functions as substrate adapter protein for the E3 ubiquitin ligase complex formed by CUL3 and RBX1. Targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. May also retain BPTF in the cytosol. Targets PGAM5 for ubiquitination and degradation by the proteasome.
General Information
| Reactivity | Rat, Mouse |
|---|---|
| Application | WB, ELISA |
| Clonality | Polyclonal |
| Conjugate | Non-conjugated |
| Uniprot | Q14145 |
| Isotype | IgG |
| Immunogen | Synthesized peptide derived from the Internal region of human Keap1. |
| Storage buffer | PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH7.3 |
| Storage instruction | Store at -20℃. Avoid freeze / thaw cycles. |
| Alias | Cytosolic inhibitor of Nrf2,INrf 2,INrf2,Keap 1,KEAP1,KEAP1,Kelch like ECH associated protein 1,Kelch like family member 19,Kelch like protein 19,Kelch-like ECH-associated protein 1,Kelch-like protein 19,KIAA0132,KLHL 19,KLHL19,MGC10630,MGC1114,MGC20887,MGC4407,MGC9454 |
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