Antibody, Antibody Sampler Kit

Insulin Receptor Substrate Antibody Sampler Kit

  • Catalog Number : AK0177
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Introduction

Insulin receptor substrate 1 (IRS-1) is one of the major substrates of the insulin receptor kinase. IRS-1 contains multiple tyrosine phosphorylation motifs that serve as docking sites for SH2-domain containing proteins that mediate the metabolic and growth-promoting functions of insulin. IRS-1 also contains over 30 potential serine/threonine phosphorylation sites. Ser307 of IRS-1 is phosphorylated by JNK and IKK while Ser789 is phosphorylated by SIK-2, a member of the AMPK family. The PKC and mTOR pathways mediate phosphorylation of IRS-1 at Ser612 and Ser636/639, respectively. Phosphorylation of IRS-1 at Ser1101 is mediated by PKCθ and results in an inhibition of insulin signaling in the cell, suggesting a potential mechanism for insulin resistance in some models of obesity.

General Information

Reactivity Human, Mouse, Rabbit
Application WB, ELISA
Host Rabbit
Storage instruction Store at -20℃. Avoid freeze / thaw cycles.
Research topic Insulin signaling pathway

PRODUCT INCLUDES

 

Cat No.

Product name

Quantity

Applications

Reactivity

Host

A340378

Phospho-IRS1 (Tyr896) Polyclonal Antibody

20μL

WB, ELISA

Human, Mouse, Rat

Rabbit

A340381

Phospho-IRS1 (Ser323) Polyclonal Antibody

20μL

WB, IHC-p, IF, ELISA

Human, Mouse, Rat, Monkey

Rabbit

A340245

Phospho-IRS1 (Ser307) Polyclonal Antibody

20μL

WB, IHC, IF, ELISA

Human, Mouse, Rat

Rabbit

A340246

Phospho-IRS1 (Ser636) Polyclonal Antibody

20μL

WB, IHC, IF, ELISA

Human, Mouse, Rat

Rabbit

A340247

Phospho-IRS1 (Ser794) Polyclonal Antibody

20μL

WB, IHC, IF, ELISA

Human, Mouse, Rat

Rabbit

A340322

Phospho-IRS1 (Ser312) Polyclonal Antibody

20μL

WB, IF, ELISA

Human, Mouse, Rat

Rabbit

A340572

IRS1 Polyclonal Antibody

20μL

WB, IHC, ELISA

Human, Mouse, Rat

Rabbit

A1013s

Goat Anti-Rabbit IgG (H+L) (peroxidase/HRP conjugated)

120μL

WB, ELISA

Rabbit

Goat

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