Antibody, Antibody Sampler Kit
IRS-1 Inhibition Antibody Sampler Kit
- Catalog Number : AK0180
- Number :
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Size:
Qty : - Price : Request Inquiry
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Introduction
Insulin receptor substrate 1 (IRS-1) is one of the major substrates of the insulin receptor kinase. IRS-1 contains multiple tyrosine phosphorylation motifs that serve as docking sites for SH2-domain containing proteins that mediate the metabolic and growth-promoting functions of insulin. IRS-1 also contains over 30 potential serine/threonine phosphorylation sites, many of which are related to negative feedback loops activated during insulin signaling. Ser307 (mouse Ser302) of IRS-1 is regulated by FOX01, IKKγ, and MYO1C. Ser312 (mouse Ser307) of IRS-1 is phosphorylated by JNK and IKK. PKC phosphorylates mouse IRS-1 at Ser323 (mouse Ser318) by insulin receptor activation or by other stimulation such as TPA, IL-6, and retinoic acid treatment. The PKC and mTOR pathways mediate phosphorylation of IRS-1 at Ser616 (mouse Ser612) and Ser636/639 (mouse Ser632/635), respectively. Phosphorylation of IRS-1 at Ser1101 (human Ser1097) is mediated by PKCθ and results in an inhibition of insulin signaling in the cell, suggesting a potential mechanism for insulin resistance in some models of obesity.
General Information
| Reactivity | Human, Mouse, Rabbit |
|---|---|
| Application | WB, ELISA |
| Host | Rabbit |
| Storage instruction | Store at -20℃. Avoid freeze / thaw cycles. |
| Research topic | Insulin signaling pathway; Insulin signaling negative feedback loops |
PRODUCT INCLUDES
|
Cat No. |
Product name |
Quantity |
Applications |
Reactivity |
Host |
|
A340244 |
Phospho-IRS1 (Ser307) Polyclonal Antibody |
20μL |
WB,IHC,ELISA |
Human, Mouse, Rat, Monkey |
Rabbit |
|
A340322 |
Phospho-IRS1 (Ser312) Polyclonal Antibody |
20μL |
WB,IF,ELISA |
Human, Mouse, Rat |
Rabbit |
|
A340246 |
Phospho-IRS1 (Ser636) Polyclonal Antibody |
20μL |
WB,IHC,IF,ELISA |
Human, Mouse, Rat |
Rabbit |
|
A340381 |
Phospho-IRS1 (Ser323) Polyclonal Antibody |
20μL |
WB,IHC-p,IF,ELISA |
Human, Mouse, Rat, Monkey |
Rabbit |
|
A340243 |
Phospho-IRS1 (Ser1101) Polyclonal Antibody |
20μL |
WB,IHC,ELISA |
Human, Mouse, Rat, Monkey |
Rabbit |
|
A340571 |
IRS1 Polyclonal Antibody |
20μL |
WB,IHC,ELISA |
Human, Mouse, Rat |
Rabbit |
|
A1013s |
Goat Anti-Rabbit IgG (H+L) (peroxidase/HRP conjugated) |
120μL |
WB, ELISA |
Rabbit |
Goat |
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