Antibody, Antibody Sampler Kit
Mismatch Repair Antibody Sampler Kit
- Catalog Number : AK0190
- Number :
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Size:
Qty : - Price : Request Inquiry
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Introduction
The DNA mismatch repair system (MMR) repairs post-replication DNA, inhibits recombination between nonidentical DNA sequences, and induces both checkpoint and apoptotic responses following certain types of DNA damage. MSH2 (MutS homologue 2) forms the hMutS-α dimer with MSH6 and is an essential component of the mismatch repair process. hMutS-α is part of the BRCA1-associated surveillance complex (BASC), a complex that also contains BRCA1, MLH1, ATM, BLM, PMS2 proteins, and the Rad50-Mre11-NBS1 complex. Mutations in MSH6 and other MMR proteins have been found in a large proportion of hereditary nonpolyposis colorectal cancer (Lynch Syndrome), the most common form of inherited colorectal cancer in the Western world. Mutations in MSH6 have been shown to occur in glioblastoma in response to temozolomide therapy and to promote temozolomide resistance.
General Information
| Reactivity | Human, Mouse, Rabbit, Monkey |
|---|---|
| Application | WB, ELISA |
| Host | Rabbit |
| Storage instruction | Store at -20℃. Avoid freeze / thaw cycles. |
| Research topic | DNA damage and repair |
PRODUCT INCLUDES
|
Cat No. |
Product name |
Quantity |
Applications |
Reactivity |
Host |
|
A340593 |
MLH1 Polyclonal Antibody |
20μL |
WB, IF, ELISA |
Human, Mouse, Rat |
Rabbit |
|
A340537 |
GTBP Polyclonal Antibody |
20μL |
WB, IHC, IF, ELISA |
Human, Mouse, Monkey |
Rabbit |
|
A1013s |
Goat Anti-Rabbit IgG (H+L) (peroxidase/HRP conjugated) |
120μL |
WB, ELISA |
Rabbit |
Goat |
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