COVID-19 , COVID-19 Related Compounds

Nafamostat (mesylate)

  • Catalog Number : C5124
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Introduction

Nafamostat mesylate, a synthetic serine protease inhibitor, is an anticoagulant. Tranilast (FUT-175) is an antiallergic drug for bronchial asthma. It has been used for the treatment of allergic disorders such as asthma, allergic rhinitis and atopic dermatitis. It has also been investigated for use as an antiproliferative drug on drug-eluting stents. A 20-40 mg/h dose of FUT-175 prolonged coagulation time sufficiently in the instrumental blood of the extracorporeal circuit but not in the systemic blood. Its anticoagulant activity decreased immediately after hemodialysis. Therefore, we could manage all patients without any bleeding trouble during hemodialysis with FUT-175 as an anticoagulant. Although there were side effects of FUT-175, such as nausea, vomiting, itching and eruption, they were not serious, and FUT-175 could be administered without interruption. FUT-175 seems to be useful as an anticoagulant during hemodialysis for patients susceptible to bleeding

General Information

Cas No. 82956-11-4
Purity >99%
Molecular Weight 539.5819
Formula C21H25N5O8S2
Solubility DMSO : 50 mg/mL/ H2O:3.33 mg/mL
Storage instruction 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

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