Antibody, In Vivo Mab

anti-HER2 (Ado-trastuzumab emtansine)

  • Catalog Number : A510009
  • Number : A510009-1mg
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Introduction

Ado-trastuzumab emtansine is a HER2-targeted antibody-drug conjugate which contains the humanized anti-HER2 IgG1, trastuzumab, covalently linked to the microtubule inhibitory drug DM1 via the stable thioether linker MCC. Trastuzumab is produced by Chinese hamster ovary cells, and DM1-MCC are produced by chemical synthesis. Ado-trastuzumab emtansine contains an average of 3.5 DM1 molecules per antibody.

General Information

Reactivity Human
Application Functional Assay
Host CHO cells
Clonality Monoclonal
Conjugate Non-conjugated
Isotype Human IgG1
Cas No. 1018448-65-1
Purity >95%; < 0.75 EU/mg as determined by the LAL method
Molecular Weight 149 kDa
Storage buffer 0.01 M phosphate buffered saline (PBS) pH 7.2
Storage instruction This solution is stable for at least 4 weeks when stored at 2-8°C. For long term storage aseptically aliquot and store at –80°C.Avoid repeated freeze/thaw cycles.

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