SOX-2 (PTR1367) Mouse mAb
- Catalog Number : AM4472
- Number : AM4472
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General Information
| Isotype | IgG1,Kappa | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Immunogen | Recombinant protein | |||||||||
| Molecular Weight | 34kD (Calculated) | 34kD (Observed) | |||||||||
| Storage buffer | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA | |||||||||
| Storage instruction | -15°C to -25°C/1 year(Do not lower than -25°C) | |||||||||
| Research topic | >>Hippo signaling pathway>>Signaling pathways regulating pluripotency of stem cells | |||||||||
| Alias | SOX2
Transcription factor SOX-2 |
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| Recommended Dilution Ratio | WB 1:500-2000.IF 1:100-500.ELISA 1:1000-5000. | |||||||||
| Specificity | This antibody detects endogenous levels of SOX-2 protein. | |||||||||
| Purification | Protein G | |||||||||
| Gene Name | SOX2 | |||||||||
| Protein Name | Transcription factor SOX-2 | |||||||||
| Database Link |
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| Background | SRY-box 2(SOX2) Homo sapiens This intronless gene encodes a member of the SRY-related HMG-box (SOX) family of transcription factors involved in the regulation of embryonic development and in the determination of cell fate. The product of this gene is required for stem-cell maintenance in the central nervous system, and also regulates gene expression in the stomach. Mutations in this gene have been associated with optic nerve hypoplasia and with syndromic microphthalmia, a severe form of structural eye malformation. This gene lies within an intron of another gene called SOX2 overlapping transcript (SOX2OT). [provided by RefSeq, Jul 2008]. | |||||||||
| Function | Disease:Defects in SOX2 are the cause of microphthalmia syndromic type 3 (MCOPS3) [MIM:206900]. Microphthalmia is a clinically heterogeneous disorder of eye formation, ranging from small size of a single eye to complete bilateral absence of ocular tissues (anophthalmia). In many cases, microphthalmia/anophthalmia occurs in association with syndromes that include non-ocular abnormalities. MCOPS3 is characterized by the rare association of malformations including uni- or bilateral anophthalmia or microphthalmia, and esophageal atresia with trachoesophageal fistula.,Function:Transcription factor that forms a trimeric complex with OCT4 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206. Critical for early embryogenesis and for embryonic stem cell pluripotency.,online information:Sox2 entry,PTM:Sumoylation inhibits binding on DNA and negatively regulates the FGF4 transactivation.,similarity:Contains 1 HMG box DNA-binding domain. | |||||||||
| Cellular Localization | Nuclear | |||||||||
| Tissue Expression | Fetal brain,Lung,Retina. | |||||||||
| Validation Data |
Whole cell lysates were separated by 10% SDS-PAGE, and the membrane was blotted with anti-SOX-2 (PTR1367) antibody. The HRP-conjugated Goat anti-Rabbit IgG(H + L) antibody was used to detect the antibody. Lane 1: NCCIT Predicted band size: 34kDa Observed band size: 34kDa |
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