Acetyl-Histone Antibody Sampler Kit

Catalog Number : AK0103
Number :
Size:
Qty :
Price : Request Inquiry

Introduction

Modulation of chromatin structure plays an important role in the regulation of transcription in eukaryotes. The nucleosome, made up of DNA wound around eight core histone proteins (two each of H2A, H2B, H3, and H4), is the primary building block of chromatin. The amino-terminal tails of core histones undergo various post-translational modifications, including acetylation, phosphorylation, methylation, and ubiquitination. These modifications occur in response to various stimuli and have a direct effect on the accessibility of chromatin to transcription factors and, therefore, gene expression. In most species, histone H2B is primarily acetylated at Lys5, 12, 15, and 20. Histone H3 is primarily acetylated at Lys9, 14, 18, 23, 27, and 56. Acetylation of H3 at Lys9 appears to have a dominant role in histone deposition and chromatin assembly in some organisms. Phosphorylation at Ser10, Ser28, and Thr11 of histone H3 is tightly correlated with chromosome condensation during both mitosis and meiosis. Phosphorylation at Thr3 of histone H3 is highly conserved among many species and is catalyzed by the kinase haspin. Immunostaining with phospho-specific antibodies in mammalian cells reveals mitotic phosphorylation at Thr3 of H3 in prophase and its dephosphorylation during anaphase.

General Information

Reactivity	Human, Mouse, Rabbit
Application	WB, ELISA
Host	Mouse, Rabbit
Storage instruction	Store at -20℃. Avoid freeze / thaw cycles.
Research topic	Chromatin modulation; Transcriptional regulation;

PRODUCT INCLUDES

Cat No.	Product name	Quantity	Applications	Reactivity	Host
A340188	Acetyl-Histone H2B (Lys5) Polyclonal Antibody	20μL	WB	Human, Mouse, Rat	Rabbit
A340187	Acetyl-Histone H2A (Lys5) Polyclonal Antibody	20μL	WB	Human, Mouse, Rat	Rabbit
A340385	Histone H2B Monoclonal Antibody	20μL	WB	Human, Mouse, Rat	Rabbit
A340406	Histone H2A Polyclonal Antibody	20μL	WB, ELISA	Human, Mouse, Rat	Rabbit
A340385	Histone H3 Monoclonal Antibody	20μL	WB, IF, IP	Human, Mouse, Rat, Yeast	Mouse
A340185	Acetyl-Histone H3 (Lys9) Polyclonal Antibody	20μL	WB	Human, Mouse, Rat	Rabbit
A340547	Histone H4 Polyclonal Antibody	20μL	WB, IHC, IF, ELISA	Human, Mouse, Rat, Monkey	Rabbit
A340179	Acetyl-Histone H4 (Lys8) Polyclonal Antibody	20μL	WB, IHC, IF, ELISA	Human, Mouse, Rat, Monkey	Rabbit
A1013s	Goat Anti-Rabbit IgG (H+L) (peroxidase/HRP conjugated)	120μL	WB, ELISA	Rabbit	Goat
A1012s	Goat Anti-Mouse IgG (H+L) (peroxidase/HRP conjugated)	120μL	WB, ELISA	Mouse	Goat

Acetyl-Histone Antibody Sampler Kit

Introduction

General Information

Recently Viewed Products

Acetyl-Histone Antibody Sampler Kit

Send us your inquiry