Antibody, Antibody Sampler Kit

Acetyl-Histone Antibody Sampler Kit

  • Catalog Number : AK0103
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Introduction

Modulation of chromatin structure plays an important role in the regulation of transcription in eukaryotes. The nucleosome, made up of DNA wound around eight core histone proteins (two each of H2A, H2B, H3, and H4), is the primary building block of chromatin. The amino-terminal tails of core histones undergo various post-translational modifications, including acetylation, phosphorylation, methylation, and ubiquitination. These modifications occur in response to various stimuli and have a direct effect on the accessibility of chromatin to transcription factors and, therefore, gene expression. In most species, histone H2B is primarily acetylated at Lys5, 12, 15, and 20. Histone H3 is primarily acetylated at Lys9, 14, 18, 23, 27, and 56. Acetylation of H3 at Lys9 appears to have a dominant role in histone deposition and chromatin assembly in some organisms. Phosphorylation at Ser10, Ser28, and Thr11 of histone H3 is tightly correlated with chromosome condensation during both mitosis and meiosis. Phosphorylation at Thr3 of histone H3 is highly conserved among many species and is catalyzed by the kinase haspin. Immunostaining with phospho-specific antibodies in mammalian cells reveals mitotic phosphorylation at Thr3 of H3 in prophase and its dephosphorylation during anaphase.

General Information

Reactivity Human, Mouse, Rabbit
Application WB, ELISA
Host Mouse, Rabbit
Storage instruction Store at -20℃. Avoid freeze / thaw cycles.
Research topic Chromatin modulation; Transcriptional regulation;

PRODUCT INCLUDES

Cat No.

Product name

Quantity

Applications

Reactivity

Host

A340188

Acetyl-Histone H2B (Lys5) Polyclonal Antibody

20μL

WB

Human, Mouse, Rat

Rabbit

A340187

Acetyl-Histone H2A (Lys5) Polyclonal Antibody

20μL

WB

Human, Mouse, Rat

Rabbit

A340385

Histone H2B Monoclonal Antibody

20μL

WB

Human, Mouse, Rat

Rabbit

A340406

Histone H2A Polyclonal Antibody

20μL

WB, ELISA

Human, Mouse, Rat

Rabbit

A340385

Histone H3 Monoclonal Antibody

20μL

WB, IF, IP

Human, Mouse, Rat, Yeast

Mouse

A340185

Acetyl-Histone H3 (Lys9) Polyclonal Antibody

20μL

WB

Human, Mouse, Rat

Rabbit

A340547

Histone H4 Polyclonal Antibody

20μL

WB, IHC, IF, ELISA

Human, Mouse, Rat, Monkey

Rabbit

A340179

Acetyl-Histone H4 (Lys8) Polyclonal Antibody

20μL

WB, IHC, IF, ELISA

Human, Mouse, Rat, Monkey

Rabbit

A1013s

Goat Anti-Rabbit IgG (H+L) (peroxidase/HRP conjugated)

120μL

WB, ELISA

Rabbit

Goat

A1012s

Goat Anti-Mouse IgG (H+L) (peroxidase/HRP conjugated)

120μL

WB, ELISA

Mouse

Goat

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