Antibody, Antibody Sampler Kit

Acetyl-Histone H4 Antibody Sampler Kit

  • Catalog Number : AK0105
  • Number :
  • Size:
    Qty :
  • Price : Request Inquiry
  • Download DataSheet print

Introduction

Modulation of chromatin structure plays an important role in the regulation of transcription in eukaryotes. The nucleosome, made up of DNA wound around eight core histone proteins (two each of H2A, H2B, H3, and H4), is the primary building block of chromatin. The amino-terminal tails of core histones undergo various post-translational modifications, including acetylation, phosphorylation, methylation, and ubiquitination. These modifications occur in response to various stimuli and have a direct effect on the accessibility of chromatin to transcription factors and, therefore, gene expression. In most species, histone H2B is primarily acetylated at Lys5, 12, 15, and 20. Histone H3 is primarily acetylated at Lys9, 14, 18, 23, 27, and 56. Acetylation of H3 at Lys9 appears to have a dominant role in histone deposition and chromatin assembly in some organisms. Phosphorylation at Ser10, Ser28, and Thr11 of histone H3 is tightly correlated with chromosome condensation during both mitosis and meiosis. Phosphorylation at Thr3 of histone H3 is highly conserved among many species and is catalyzed by the kinase haspin. Immunostaining with phospho-specific antibodies in mammalian cells reveals mitotic phosphorylation at Thr3 of H3 in prophase and its dephosphorylation during anaphase.

General Information

Reactivity Human, Mouse, Rabbit
Application WB, ELISA
Host Rabbit
Clonality Polyclonal
Conjugate HRP,Non-conjugated
Storage instruction Store at -20℃. Avoid freeze / thaw cycles.
Research topic Chromatin modulation; Transcriptional regulation;

Product Includes

Product name Quantity  Applications Reactivity Host
Histone H4 Polyclonal Antibody 20μL WB,IHC,IF,ELISA Human, Mouse, Rat, Monkey Rabbit
Acetyl-Histone H4 (Lys5) Polyclonal Antibody 20μL WB,IHC,IF,ELISA Human, Mouse, Rat, Monkey Rabbit
Acetyl-Histone H4 (Lys8) Polyclonal Antibody 20μL WB,IHC,IF,ELISA Human, Mouse, Rat, Monkey Rabbit
Acetyl-Histone H4 (Lys12) Polyclonal Antibody 20μL WB,IHC,IF,ELISA Human, Mouse, Rat, Monkey Rabbit
Acetyl-Histone H4 (Lys16) Polyclonal Antibody 20μL WB,IHC,IF,ELISA Human, Mouse, Rat Rabbit
Acetyl-Histone H4 (Lys91) Polyclonal Antibody 20μL WB Human, Mouse, Rat Rabbit
Goat Anti-Rabbit IgG (H+L)(peroxidase/HRP conjugated) 120μL WB,ELISA    

Recently Viewed Products

gotop link
Customized Product Contact Us
0