Histone Deacetylase (HDAC) Antibody Sampler Kit

Catalog Number : AK0169
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Introduction

Acetylation of the histone tail causes chromatin to adopt an "open" conformation, allowing increased accessibility of transcription factors to DNA. The identification of histone acetyltransferases (HATs) and their large multiprotein complexes has yielded important insights into how these enzymes regulate transcription. HAT complexes interact with sequence-specific activator proteins to target specific genes. In addition to histones, HATs can acetylate nonhistone proteins, suggesting multiple roles for these enzymes. In contrast, histone deacetylation promotes a "closed" chromatin conformation and typically leads to repression of gene activity. Mammalian histone deacetylases can be divided into three classes on the basis of their similarity to various yeast deacetylases. Class I proteins (HDACs 1, 2, 3, and 8) are related to the yeast Rpd3-like proteins, those in class II (HDACs 4, 5, 6, 7, 9, and 10) are related to yeast Hda1-like proteins, and class III proteins are related to the yeast protein Sir2. Inhibitors of HDAC activity are now being explored as potential therapeutic cancer agents.

General Information

Reactivity	Human, Mouse
Application	WB, ELISA
Host	Rabbit
Clonality	Polyclonal
Conjugate	HRP,Non-conjugated
Storage instruction	Store at -20℃. Avoid freeze / thaw cycles.
Research topic	Chromatin modulation; Transcriptional regulation

PRODUCT INCLUDES

Cat No.	Product name	Quantity	Applications	Reactivity	Host
A340538	HDAC1 Polyclonal Antibody	20μL	WB, IHC, ELISA	Human, Mouse, Rat	Rabbit
A340539	HDAC2 Polyclonal Antibody	20μL	WB, IHC, ELISA	Human, Mouse, Rat, Monkey	Rabbit
A340294	Phospho-HDAC2 (Ser394) Polyclonal Antibody	20μL	WB, ELISA	Human, Mouse, Rat, Monkey	Rabbit
A340540	HDAC3 Polyclonal Antibody	20μL	WB, IHC, IF, ELISA	Human, Mouse, Rat	Rabbit
A340541	HDAC4 Polyclonal Antibody	20μL	WB, ELISA	Human, Mouse, Rat	Rabbit
A340232	Phospho-HDAC4 (Ser632) Polyclonal Antibody	20μL	WB, ELISA	Human, Mouse, Rat	Rabbit
A340542	HDAC5 Polyclonal Antibody	20μL	WB, IHC, IF, ELISA	Human, Mouse	Rabbit
A340233	Phospho-HDAC5 (Ser498) Polyclonal Antibody	20μL	WB, IHC, IF, ELISA	Human, Mouse	Rabbit
A340543	HDAC5/9 Polyclonal Antibody	20μL	WB, IHC, ELISA	Human, Mouse	Rabbit
A340544	HDAC6 Polyclonal Antibody	20μL	WB, IHC, IF, ELISA	Human, Mouse	Rabbit
A340368	Phospho-HDAC6 (Ser22) Polyclonal Antibody	20μL	WB, IHC, IF, ELISA	Human, Mouse	Rabbit
A1013s	Goat Anti-Rabbit IgG (H+L) (peroxidase/HRP conjugated)	120μL	WB, ELISA	Rabbit	Goat

Histone Deacetylase (HDAC) Antibody Sampler Kit

Introduction

General Information

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Histone Deacetylase (HDAC) Antibody Sampler Kit

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