Antibody, Antibody Sampler Kit
Met Signaling Antibody Sampler Kit
- Catalog Number : AK0188
- Number :
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Size:
Qty : - Price : Request Inquiry
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Introduction
Met, a high affinity tyrosine kinase receptor for hepatocyte growth factor (HGF, also known as scatter factor), is a disulfide-linked heterodimer made of 45 kDa α- and 145 kDa β-subunits. The α-subunit and the amino-terminal region of the β-subunit form the extracellular domain. The remainder of the β-chain spans the plasma membrane and contains a cytoplasmic region with tyrosine kinase activity. Interaction of Met with HGF results in autophosphorylation at multiple tyrosines, which recruit several downstream signaling components, including Gab1, c-Cbl and PI3 kinase. These fundamental events are important for all of the biological functions involving Met kinase activity. Addition of a phosphate at cytoplasmic Tyr1003 is essential for ubiquitination and Met protein degradation. Phosphorylation of Tyr1234/1235 in the Met kinase domain is critical to kinase activation. Phosphorylation of Tyr1349 in the Met cytoplasmic domain provides a direct binding site for Gab1. Altered Met levels and/or tyrosine kinase activities are found in several types of tumors, including renal, colon and breast cancers. Thus, Met is an attractive cancer therapeutic and diagnostic target.
General Information
| Reactivity | Human, Mouse, Rabbit |
|---|---|
| Application | WB, ELISA |
| Host | Rabbit |
| Clonality | Polyclonal |
| Conjugate | HRP,Non-conjugated |
| Storage instruction | Store at -20℃. Avoid freeze / thaw cycles. |
| Research topic | Met signaling pathway |
PRODUCT INCLUDES
|
Cat No. |
Product name |
Quantity |
Applications |
Reactivity |
Host |
|
A340228 |
Phospho-GAB1 (Tyr627) Polyclonal Antibody |
20μL |
WB, ELISA |
Human, Mouse, Monkey |
Rabbit |
|
A340367 |
Phospho-GAB1 (Tyr659) Polyclonal Antibody |
20μL |
WB, IHC, IF, ELISA |
Human, Mouse, Rat |
Rabbit |
|
A340592 |
MET Polyclonal Antibody |
20μL |
WB, ELISA |
Human |
Rabbit |
|
A340255 |
Phospho-MET (Tyr1234) Polyclonal Antibody |
20μL |
WB, ELISA |
Human, Mouse, Rat, Monkey |
Rabbit |
|
A340256 |
Phospho-MET (Tyr1349) Polyclonal Antibody |
20μL |
WB, ELISA |
Human, Mouse, Rat |
Rabbit |
|
A340298 |
Phospho-MET (Tyr1356) Polyclonal Antibody |
20μL |
WB, ELISA |
Human, Mouse, Rat |
Rabbit |
|
A1013s |
Goat Anti-Rabbit IgG (H+L) (peroxidase/HRP conjugated) |
120μL |
WB, ELISA |
Rabbit |
Goat |
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