JAK1 protein
- Catalog Number : AD0054
- Number : AD0054
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General Information
| Reactivity | Human | |||||||||
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| Application | WB | |||||||||
| Purity | SDS-PAGE >90% | |||||||||
| Storage buffer | Liquid in PBS | |||||||||
| Storage instruction | -20°C/6 month,-80°C for long storage | |||||||||
| Alias | Tyrosine-protein kinase JAK1
Janus kinase 1 JAK-1 |
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| Recommended Dilution Ratio | WB 1:500-2000 | |||||||||
| Source | E.coli | |||||||||
| Sequence | Amino acid: 1-189, with his-MBP tag. | |||||||||
| Gene Name | JAK1 | |||||||||
| Protein Name | JAK1 protein | |||||||||
| Database Link |
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| Background | catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.,domain:Possesses two phosphotransferase domains. The second one probably contains the catalytic domain (By similarity), while the presence of slight differences suggest a different role for domain 1.,domain:The FERM domain mediates interaction with JAKMIP1.,function:Tyrosine kinase of the non-receptor type, involved in the IFN-alpha/beta/gamma signal pathway. Kinase partner for the interleukin (IL)-2 receptor.,sequence caution:Translation N-terminally extended.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. JAK subfamily.,similarity:Contains 1 FERM domain.,similarity:Contains 1 protein kinase domain.,similarity:Contains 1 SH2 domain.,subcellular location:Wholly intracellular, possibly membrane associated.,subunit:Interacts with IL31RA, JAKMIP1 and SHB.,tissue specificity:Expressed at higher levels in primary colon tumors than in normal colon tissue. The expression level in metastatic colon tumors is comparable to the expression level in normal colon tissue. | |||||||||
| Function | protein amino acid phosphorylation, phosphorus metabolic process, phosphate metabolic process, cell surface receptor linked signal transduction, enzyme linked receptor protein signaling pathway, intracellular signaling cascade,protein kinase cascade, phosphorylation, peptidyl-tyrosine phosphorylation, peptidyl-tyrosine modification, cytokine-mediated signaling pathway, response to antibiotic. | |||||||||
| Cellular Localization | Endomembrane system; Peripheral membrane protein. Wholly intracellular, possibly membrane associated. | |||||||||
| Tissue Expression | Expressed at higher levels in primary colon tumors than in normal colon tissue. The expression level in metastatic colon tumors is comparable to the expression level in normal colon tissue. |
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