Phospho-c-SRC (Tyr419) Polyclonal Antibody
- Catalog Number : A340295
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Introduction
Non-receptor protein tyrosine kinase that plays pivotal roles in numerous cellular processes such as proliferation, migration, and transformation. In concert with PTK2B, plays an important role in osteoclastic bone resorption. Both the formation of a SRC-PTK2B complex, and SRC kinase activity are necessary for this function. Once it is recruited to the activated integrins, by PTK2B, it phosphorylates CBL which in turn induces the activation and recruitment of phosphatidylinositol 3-kinase to the cell membrane in a signaling pathway that is critical for osteoclast function. Promotes energy production in osteoclasts by activating mitochondrial cytochrome C oxidase. Phosphorylates RUNX3 and COX2 on tyrosine residues, TNK2 on 'Tyr-284' and CBL on 'Tyr-731'. Enhances DDX58/RIG-I-elicited antiviral signaling.
General Information
| Reactivity | Rat, Mouse |
|---|---|
| Application | WB, IHC, ELISA |
| Clonality | Polyclonal |
| Conjugate | Non-conjugated |
| Uniprot | Human: P12931, Mouse: P05480, Rat: Q9WUD9 |
| Immunogen | The antiserum was produced against synthesized peptide derived from human Src around the phosphorylation site of Tyr418. AA rang |
| Storage buffer | PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH7.3 |
| Storage instruction | Store at -20℃. Avoid freeze / thaw cycles. |
| Alias | ASV,Avian sarcoma virus,c SRC,CDNA FLJ14219 fis clone NT2RP3003800 highly similar to Rattus norvegicus tyrosine protein kinase pp60 c src mRNA,cSrc,EC 2.7.10.2,Neuronal CSRC tyrosine specific protein kinase,Neuronal SRC,Oncogene SRC,OTTHUMP00000174476,OTTHUMP00000174477,p60 Src,p60-Src,p60Src,pp60c src,pp60c-src,pp60csrc,Proto oncogene tyrosine protein kinase Src,Proto-oncogene c-Src,Proto-oncogene tyrosine-protein kinase Src,Protooncogene SRC,Protooncogene SRC Rous sarcoma,Src,SRC Oncogene,SRC proto oncogene non receptor tyrosine kinase,SRC,SRC1,Tyrosine kinase pp60c src,Tyrosine protein kinase SRC 1,Tyrosine protein kinase SRC1,v src avian sarcoma (Schmidt Ruppin A2) viral oncogene homolog,V src sarcoma (Schmidt Ruppin A 2) viral oncogene homolog (avian),v src sarcoma (Schmidt Ruppin A 2) viral oncogene homolog avian |
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