Phospho-FAK (Tyr397) Polyclonal Antibody
- Catalog Number : A340315
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Introduction
Non-receptor protein-tyrosine kinase implicated in signaling pathways involved in cell motility, proliferation and apoptosis. Activated by tyrosine-phosphorylation in response to either integrin clustering induced by cell adhesion or antibody cross-linking, or via G-protein coupled receptor (GPCR) occupancy by ligands such as bombesin or lysophosphatidic acid, or via LDL receptor occupancy. Microtubule-induced dephosphorylation at Tyr-397 is crucial for the induction of focal adhesion disassembly. Plays a potential role in oncogenic transformations resulting in increased kinase activity.
General Information
| Reactivity | Rat, Mouse |
|---|---|
| Application | WB, ELISA |
| Clonality | Polyclonal |
| Conjugate | Non-conjugated |
| Uniprot | Q05397 |
| Isotype | IgG |
| Immunogen | Synthesized peptide derived from human FAK around the phosphorylation site of Tyr397 |
| Storage buffer | PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH7.3 |
| Storage instruction | Store at -20℃. Avoid freeze / thaw cycles. |
| Alias | FADK 1,FADK,FAK related non kinase polypeptide,FAK1,FAK1,Focal adhesion kinase 1,Focal adhesion Kinase,Focal adhesion kinase isoform FAK Del33,Focal adhesion kinase related nonkinase,FRNK,p125FAK,pp125FAK,PPP1R71,Protein phosphatase 1 regulatory subunit 71,Protein tyrosine kinase 2,Protein-tyrosine kinase 2,Ptk2,PTK2 protein tyrosine kinase 2 |
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