Phospho-RPS6KA5 (Ser376) Polyclonal Antibody
- Catalog Number : A340317
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Introduction
Serine/threonine kinase required for the mitogen or stress-induced phosphorylation of the transcription factors CREB (cAMP response element-binding protein) and ATF1 (activating transcription factor-1). Essential role in the control of RELA transcriptional activity in response to TNF. Directly represses transcription via phosphorylation of 'Ser-1' of histone H2A. Phosphorylates 'Ser-10' of histone H3 in response to mitogenics, stress stimuli and epidemal growth-factor (EGF), which results in the transcriptional activation of several immediate early genes, including proto-oncogenes c-fos/FOS and c-jun/JUN. May also phosphorylate 'Ser-28' of histone H3. Mediates the mitogen- and stress-induced phosphorylation of high mobility group protein 14 (HMG-14).
General Information
| Reactivity | Mouse |
|---|---|
| Application | WB, IF, ELISA |
| Clonality | Polyclonal |
| Conjugate | Non-conjugated |
| Uniprot | O75582 |
| Isotype | IgG |
| Immunogen | Synthesized peptide derived from human MSK1 around the phosphorylation site of Ser376 |
| Storage buffer | PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH7.3 |
| Storage instruction | Store at -20℃. Avoid freeze / thaw cycles. |
| Alias | 90 kDa ribosomal protein S6 kinase 5,EC 2.7.11.1,KS6A5,MGC1911,Mitogen and stress activated protein kinase 1,MSPK1,Nuclear Mitogen And Stress Activated Protein Kinase 1,Nuclear mitogen- and stress-activated protein kinase 1,Ribosomal protein S6 kinase 90kD polypeptide 5,Ribosomal protein S6 kinase 90kDa,Ribosomal protein S6 kinase 90kDa polypeptide 5,Ribosomal Protein S6 Kinase Alpha 5,Ribosomal protein S6 kinase alpha-5,RLPK,RPS6KA5,RSK Like Protein Kinase,RSK-like protein kinase,RSKL,S6K alpha 5,S6K-alpha-5 |
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