Phospho-AURKA (Thr288) Polyclonal Antibody
- Catalog Number : A340342
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Introduction
Contributes to the regulation of cell cycle progression. Required for normal mitosis. Associates with the centrosome and the spindle microtubules during mitosis and functions in centrosome maturation, spindle assembly, maintenance of spindle bipolarity, centrosome separation and mitotic checkpoint control. Phosphorylates numerous target proteins, including ARHGEF2, BRCA1, KIF2A, NDEL1, PARD3, PLK1 and BORA. Regulates KIF2A tubulin depolymerase activity (By similarity). Required for normal axon formation. Plays a role in microtubule remodeling during neurite extension. Important for microtubule formation and/or stabilization.
General Information
| Reactivity | Rat, Mouse |
|---|---|
| Application | WB, IHC, ELISA |
| Clonality | Polyclonal |
| Conjugate | Non-conjugated |
| Uniprot | O14965 |
| Isotype | IgG |
| Immunogen | Synthesized peptide derived from human ARK-1 around the phosphorylation site of T288. |
| Storage buffer | PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH7.3 |
| Storage instruction | Store at -20℃. Avoid freeze / thaw cycles. |
| Alias | AIK,ARK-1,ARK1,AURA,Aurka,Aurora 2,Aurora A,Aurora kinase A,Aurora-related kinase 1,Aurora/IPL1 like kinase,Aurora/IPL1-related kinase 1,AURORA2,Breast tumor-amplified kinase,BTAK,hARK1,IAK,IPL1 related kinase, Protein phosphatase 1,regulatory subunit 47,Serine/threonine kinase 15,Serine/threonine kinase 6,Serine/threonine-protein kinase 15,Serine/threonine-protein kinase 6,Serine/threonine-protein kinase aurora-A,STK15,STK6,STK6,STK7 |
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