AMPK beta1 Polyclonal Antibody
- Catalog Number : A340426
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Introduction
Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Beta non-catalytic subunit acts as a scaffold on which the AMPK complex assembles, via its C-terminus that bridges alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1, PRKAG2 or PRKAG3).
General Information
| Reactivity | Rat, Mouse, Monkey |
|---|---|
| Application | WB, IHC, ELISA |
| Clonality | Polyclonal |
| Conjugate | Non-conjugated |
| Uniprot | Q9Y478 |
| Isotype | IgG |
| Immunogen | Synthesized peptide derived from human AMPKβ1 around the non-phosphorylation site of S182. |
| Storage buffer | PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH7.3 |
| Storage instruction | Store at -20℃. Avoid freeze / thaw cycles. |
| Alias | 1300015D22Rik,5''-AMP-activated protein kinase subunit beta-1,5'-AMP-activated protein kinase beta-1 subunit,AAKB1,AMP-activated protein kinase beta subunit,AMP-ACTIVATED PROTEIN KINASE,NONCATALYTIC,BETA-1,AMP-activated,noncatalytic,beta-1,AMPK,AMPK beta 1 chain,AMPK subunit beta-1,AMPK-BETA-1,AMPKb,AU021155,E430008F22,HAMPKb,MGC17785,PRKAB1,Protein kinase AMP activated non catalytic subunit beta 1,protein kinase,AMP-activated,beta 1 non-catalytic subunit,protein kinase,AMP-activated,noncatalytic,beta-1 |
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