AMPK gamma1 Polyclonal Antibody
- Catalog Number : A340427
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Introduction
AMP/ATP-binding subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Gamma non-catalytic subunit mediates binding to AMP, ADP and ATP, leading to activate or inhibit AMPK: AMP-binding results in allosteric activation of alpha catalytic subunit (PRKAA1 or PRKAA2) both by inducing phosphorylation and preventing dephosphorylation of catalytic subunits. ADP also stimulates phosphorylation, without stimulating already phosphorylated catalytic subunit. ATP promotes dephosphorylation of catalytic subunit, rendering the AMPK enzyme inactive.
General Information
| Reactivity | Rat, Mouse |
|---|---|
| Application | WB, ELISA |
| Clonality | Polyclonal |
| Conjugate | Non-conjugated |
| Uniprot | P54619 |
| Isotype | IgG |
| Immunogen | Synthesized peptide derived from the N-terminal region of human AMPKγ1 |
| Storage buffer | PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH7.3 |
| Storage instruction | Store at -20℃. Avoid freeze / thaw cycles. |
| Alias | 5' AMP activated protein kinase gamma 1 subunit,5' AMP activated protein kinase subunit gamma 1,5''-AMP-activated protein kinase subunit gamma-1,AAKG1,AMP activated protein kinase noncatalytic gamma 1 subunit,AMPK gamma 1 chain,AMPK gamma1,AMPK subunit gamma-1,AMPKg,MGC8666,PRKAG 1,PRKAG1,Protein kinase AMP activated gamma 1 non catalytic subunit,protein kinase,AMP-activated,noncatalytic gamma-1 |
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