CDK7 Polyclonal Antibody
- Catalog Number : A340478
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Introduction
Cyclin-dependent kinases (CDKs) are activated by the binding to a cyclin and mediate the progression through the cell cycle. Each different complex controls a specific transition between two subsequent phases in the cell cycle. CDK7 is the catalytic subunit of the CDK-activating kinase (CAK) complex, a serine-threonine kinase. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminus domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II. Its expression and activity are constant throughout the cell cycle.
General Information
| Reactivity | Mouse |
|---|---|
| Application | WB, IHC, ELISA |
| Clonality | Polyclonal |
| Conjugate | Non-conjugated |
| Uniprot | P50613 |
| Isotype | IgG |
| Immunogen | Synthesized peptide derived from the C-terminal region of human Cdk7 |
| Storage buffer | PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH7.3 |
| Storage instruction | Store at -20℃. Avoid freeze / thaw cycles. |
| Alias | 39 kDa protein kinase,CAK,CAK1,Cdk activating kinase,CDK-activating kinase 1,CDK-activating kinase,cdk7,CDK7,CDKN7,Cell division protein kinase 7,Cyclin dependent kinase 7,cyclin-dependent kinase 7 (MO15 homolog,Xenopus laevis,cdk-activating kinase),Cyclin-dependent kinase 7,HCAK,Homolog of Xenopus MO15 Cdk activating kinase,Kinase subunit of CAK,MO15,MO15,Xenopus,homolog of,P39 Mo15,p39MO15,Serine threonine kinase Stk1,Serine/threonine protein kinase 1,Serine/threonine protein kinase MO15,STK1,TFIIH basal transcription factor complex kinase subunit |
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