MEF2C Polyclonal Antibody
- Catalog Number : A340589
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Introduction
Transcription activator which binds specifically to the MEF2 element present in the regulatory regions of many muscle-specific genes. Controls cardiac morphogenesis and myogenesis, and is also involved in vascular development. Plays an essential role in hippocampal-dependent learning and memory by suppressing the number of excitatory synapses and thus regulating basal and evoked synaptic transmission. Crucial for normal neuronal development, distribution, and electrical activity in the neocortex. Necessary for proper development of megakaryocytes and platelets and for bone marrow B lymphopoiesis. Required for B-cell survival and proliferation in response to BCR stimulation, efficient IgG1 antibody responses to T-cell-dependent antigens and for normal induction of germinal center B cells. May also be involved in neurogenesis and in the development of cortical architecture (By similarity). Isoform 3 and isoform 4, which lack the repressor domain, are more active than isoform 1 and isoform 2.
General Information
| Reactivity | Mouse |
|---|---|
| Application | WB, IHC, ELISA |
| Clonality | Polyclonal |
| Conjugate | Non-conjugated |
| Uniprot | Q06413 |
| Isotype | IgG |
| Immunogen | Synthesized peptide derived from human MEF-2C around the non-phosphorylation site of Ser396. |
| Storage buffer | PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH7.3 |
| Storage instruction | Store at -20℃. Avoid freeze / thaw cycles. |
| Alias | C5DELq14.3,DEL5q14.3,MADS box transcription enhancer factor 2 polypeptide C (myocyte enhancer factor 2C),MADS box transcription enhancer factor 2,polypeptide C,MEF2C,MEF2C,Myocyte enhancer factor 2C,Myocyte specific enhancer factor 2C,Myocyte-specific enhancer factor 2C,OTTHUMP00000222409,Similar to MADS box transcription enhancer factor 2 polypeptide C |
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