EEA1 Polyclonal Antibody

Catalog Number : A340705
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Introduction

EEA1 is an early endosomal marker and a Rab5 effector protein essential for early endosomal membrane fusion and trafficking. The carboxy terminus of EEA1 contains a FYVE domain which binds to phosphatidylinositol-3-phosphate (PtdIns(3)P), targeting EEA1 to early endosomes. The stable association of EEA1 with the endosomal membrane is regulated by PI3 kinase, Rab5 and calcium/calmodulin. Once on the membrane, EEA1 interacts with Rab5, NSF and syntaxin 13 to promote early endosomal membrane docking and fusion.

General Information

Reactivity	Mouse
Application	WB, ELISA
Clonality	Polyclonal
Conjugate	Non-conjugated
Uniprot	Q15075
Isotype	IgG
Immunogen	Synthesized peptide derived from the N-terminal region of human EEA1.
Storage buffer	PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH7.3
Storage instruction	Store at -20℃. Avoid freeze / thaw cycles.
Alias	Early endosome antigen 1,Early endosome antigen 1,162kD,Early endosome associated protein,EEA 1,EEA1,EEA1,Endosome associated protein p162,Endosome-associated protein p162,MST105,MSTP105,ZFYVE2,Zinc finger FYVE domain containing protein 2,Zinc finger FYVE domain-containing protein 2