LYN Polyclonal Antibody
- Catalog Number : A340717
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Introduction
Down regulates expression of stem cell growth factor receptor (KIT). Acts as an effector of EpoR (erythropoietin receptor) in controlling KIT expression and may play a central role in erythroid differentiation during the switch between proliferation and maturation (By similarity). Acts as a positive regulator of cell movement while negatively regulating adhesion to stromal cells by inhibiting the ICAM-1-binding activity of beta-2 integrins. Acts as the mediator that relays suppressing signals from the chemokine receptor CXCR4 to beta-2 integrin LFA-1 in hematopoietic precursors. Involved in induction of stress-activated protein kinase (SAPK), but not ERK or p38 MAPK, in response to genotoxic agents. Induces SAPK by a MKK7- and MEKK1-dependent mechanism. The LYN -> MEKK1 -> MKK7 -> SAPK pathway is functional in the induction of apoptosis by genotoxic agents.
General Information
| Reactivity | Rat, Mouse |
|---|---|
| Application | WB, ELISA |
| Clonality | Polyclonal |
| Conjugate | Non-conjugated |
| Uniprot | P07948 |
| Isotype | IgG |
| Immunogen | Synthesized peptide derived from human Lyn around the non-phosphorylation site of Tyr192. |
| Storage buffer | PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH7.3 |
| Storage instruction | Store at -20℃. Avoid freeze / thaw cycles. |
| Alias | AA407514,EC 2.7.10.2,FLJ26625,Hck 2,JTK 8,JTK8,Lck/Yes related novel protein tyrosine kinase,LYN,LYN proto oncogene,Src family tyrosine kinase,LYN,ONCOGENE LYN,p53Lyn,p56Lyn,Tyrosine protein kinase LYN,Tyrosine-protein kinase Lyn,V yes 1 Yamaguchi sarcoma viral related oncogene homolog,Yamaguchi sarcoma viral (v yes 1) related oncogene homolog |
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