PERK Polyclonal Antibody
- Catalog Number : A340731
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Introduction
Phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2 (EIF2), leading to its inactivation and thus to a rapid reduction of translational initiation and repression of global protein synthesis. Serves as a critical effector of unfolded protein response (UPR)-induced G1 growth arrest due to the loss of cyclin D1.
General Information
| Reactivity | Rat, Mouse |
|---|---|
| Application | WB, ELISA, IHC-p |
| Clonality | Polyclonal |
| Conjugate | Non-conjugated |
| Uniprot | Q9NZJ5 |
| Isotype | IgG |
| Immunogen | Synthesized peptide derived from human PERK around the non-phosphorylation site of Thr981. |
| Storage buffer | PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH7.3 |
| Storage instruction | Store at -20℃. Avoid freeze / thaw cycles. |
| Alias | DKFZp781H1925,E2AK3,EC 2.7.11.1,Eif2ak3,Eukaryotic translation initiation factor 2 alpha kinase 3,Eukaryotic translation initiation factor 2-alpha kinase 3,Heme regulated EIF2 alpha kinase,HRI,HsPEK,Pancreatic eIF2 alpha kinase,Pancreatic eIF2-alpha kinase,PEK,PRKR like endoplasmic reticulum kinase,PRKR-like endoplasmic reticulum kinase,WRS |
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