AMPK beta2 Polyclonal Antibody
- Catalog Number : A340738
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Introduction
PRKAB2 (Protein Kinase AMP-Activated Non-Catalytic Subunit Beta 2) is a Protein Coding gene. Among its related pathways are RET signaling and Regulation of TP53 Activity. GO annotations related to this gene include identical protein binding and AMP-activated protein kinase activity. An important paralog of this gene is PRKAB1.The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit may be a positive regulator of AMPK activity. It is highly expressed in skeletal muscle and thus may have tissue-specific roles. Multiple alternatively spliced transcript variants have been found for this gene.
General Information
| Reactivity | Rat, Mouse |
|---|---|
| Application | WB |
| Clonality | Polyclonal |
| Conjugate | Non-conjugated |
| Uniprot | O43741 |
| Isotype | IgG |
| Immunogen | Recombinant Protein |
| Storage buffer | PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH7.3 |
| Storage instruction | Store at -20℃. Avoid freeze / thaw cycles. |
| Alias | 5' AMP activated protein kinase beta 2 subunit,5' AMP activated protein kinase subunit beta 2,5''-AMP-activated protein kinase subunit beta-2,AAKB2,AMP activated protein kinase beta 2 non catalytic subunit,AMPK beta 2,AMPK beta 2 chain,AMPK subunit beta 2,AMPK subunit beta-2,MGC61468,PRKAB 2,Prkab2,Protein kinase AMP activated beta 2 non catalytic subunit |
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