Antibody, Antibody Sampler Kit

Actin Nucleation and Polymerization Antibody Sampler Kit

  • Catalog Number : AK0106
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Actin nucleation is the process of forming new actin filaments and is necessary to stimulate actin polymerization. Actin polymerization is vital for cell motility, cell division, and cell adhesion. Rac and Cdc42, members of the Rho-GTPase family, play key roles in actin dynamics, membrane trafficking, transcriptional regulation, cell growth, and development. GTP binding stimulates the activity of Rac/Cdc42, and the hydrolysis of GTP to GDP through the intrinsic GTPase activity or Rac/Cdc42, rendering it inactive. GTP hydrolysis is aided by GTPase activating proteins (GAPs), while exchange of GDP for GTP is facilitated by guanine nucleotide exchange factors (GEFs). Another level of regulation is achieved through binding of RhoGDI, a guanine dissociation inhibitor, which retains Rho family GTPases, including Rac and Cdc42, in their inactive GDP-bound state. WAVE-2 is widely distributed, while WAVE-1 and WAVE-3 are strongly expressed in the brain. The highly conserved ARP2/3 complex is an important actin nucleation protein complex consisting of ARP2, ARP3, and ARPC1-5. The ARP2/3 complex promotes branching of existing actin filaments and formation of daughter filaments following activation by nucleation-promoting factors, such as WASP/WAVE or cortactin. Profilins are conserved actin binding proteins that affect the rate of actin polymerization by binding actin monomers and promoting exchange of ADP for ATP. Profilins bind to proteins involved in the regulation of actin dynamics including paladin, dynamin-I, VASP, and N-WASP.

General Information

Reactivity Human, Mouse, Rabbit
Application WB, ELISA
Host Rabbit
Clonality Polyclonal
Conjugate HRP,Non-conjugated
Storage instruction Store at -20℃. Avoid freeze / thaw cycles.
Research topic Cytoskeleton remodelling

Product Includes

Product name Quantity  Applications Reactivity Host
CDC42 Polyclonal Antibody 20μL WB,ELISA Human, Mouse, Rat Rabbit
WASF2 Polyclonal Antibody 20μL WB,IHC,ELISA Human, Mouse, Rat Rabbit
PFN1 Polyclonal Antibody 20μL WB,ELISA Human, Mouse, Rat Rabbit
ACTR3 Polyclonal Antibody 20μL WB,ELISA Human, Mouse, Rat Rabbit
Goat Anti-Rabbit IgG (H+L)(peroxidase/HRP conjugated) 120μL WB,ELISA    


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