Antibody, Antibody Sampler Kit
C/EBP Antibody Sampler Kit
- Catalog Number : AK0131
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Introduction
CCAAT/enhancer-binding proteins (C/EBPs) are transcription factors critical for cellular differentiation, terminal function, and inflammatory response. Six characterized family members (C/EBPα, β, δ, γ, ε, and ζ) are distributed in a variety of tissues. Translation from alternative start codons results in two C/EBPα isoforms (p42 and p30) that are strong transcriptional activators. Research studies indicate that insulin and insulin-like growth factor-I stimulate C/EBPα dephosphorylation, which may play a key role in insulin-induced repression of GLUT4 transcription. Phosphorylation of C/EBPα at Thr222, Thr226, and Ser230 by GSK-3 may be required for adipogenesis. The two forms of C/EBPβ, 38 kDa liver activating protein (LAP) and the 20 kDa liver inhibitory protein (LIP), may result from alternative translation. The 38 kDa LAP protein is a transcriptional activator while LIP may inhibit C/EBPβ transcriptional activity. Phosphorylation of C/EBPβ at distinct sites stimulates its transcriptional activity. Phosphorylation at the rat-specific site Ser105 in C/EBPβ appears essential for C/EBPβ activation in rat. C/EBPδ protein is highly expressed in adipose tissue, lung, and intestine. Increased expression of C/EBPδ mRNA levels during adipogenesis suggests that C/EBPδ plays an important role in positively regulating adipogenesis. C/EBPδ is expressed in the mammalian nervous system and plays an important role in long-term memory. CHOP is a C/EBP-homologous protein that inhibits C/EBP and LAP in a dominant-negative manner. CHOP expression is induced by cellular stresses, including starvation; induced CHOP suppresses cell cycle progression from G1 to S phase. During ER stress, the level of CHOP expression is elevated and CHOP functions to mediate programmed cell death.
General Information
| Reactivity | Human, Mouse |
|---|---|
| Application | WB, ELISA |
| Host | Rabbit |
| Clonality | Polyclonal |
| Conjugate | HRP,Non-conjugated |
| Storage instruction | Store at -20℃. Avoid freeze / thaw cycles. |
| Research topic | Transcriptional regulation |
Product Includes
| Product name | Quantity | Applications | Reactivity | Host |
| CEBP alpha Polyclonal Antibody | 20μL | WB,IHC,ELISA | Human, Mouse, Rat | Rabbit |
| Phospho-CEBP alpha (Thr230) Polyclonal Antibody | 20μL | WB,ELISA | Human, Mouse, Rat | Rabbit |
| Phospho-CEBP alpha (Ser21) Polyclonal Antibody | 20μL | WB,IHC,ELISA | Human, Mouse, Rat | Rabbit |
| CEBP beta Polyclonal Antibody | 20μL | WB,IHC,ELISA | Human, Mouse, Rat | Rabbit |
| Phospho-CEBP beta (Thr235) Polyclonal Antibody | 20μL | WB,IHC,IF,ELISA | Human, Mouse, Rat | Rabbit |
| CEBPD Polyclonal Antibody | 20μL | WB,IHC,ELISA | Human,Mouse,Rat | Rabbit |
| CHOP Polyclonal Antibody | 20μL | WB,IHC,IF,ELISA | Human,Mouse | Rabbit |
| Goat Anti-Rabbit IgG (H+L)(peroxidase/HRP conjugated) | 120μL | WB,ELISA |
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