Antibody, Primary Antibody, Monoclonal Antibody, COVID-19 , COVID-19 antibody

Anti-S (SARS-CoV-2) Rabbit monoclonal antibody

  • Catalog Number : A540105
  • Number : A540105-50ul
  • Size:
    Qty :
  • Price : Request 詢價
  • Stock : Request
  • Download DataSheet print

Introduction

Specificity : 2019-nCoV CoV spike/S
[Has cross-reactivity in ELISA with SARS Coronavirus Spike Protein (S1 Subunit), SARS Coronavirus Spike RBD.]
The spike (S) glycoprotein of coronaviruses contains protrusions that will only bind to certain receptors on the host cell. Known receptors bind S1 are ACE2, angiotensin-converting enzyme 2; DPP4, dipeptidyl peptidase-4; APN, aminopeptidase N; CEACAM, carcinoembryonic antigen-related cell adhesion molecule 1; Sia, sialic acid; O-ac Sia, O-acetylated sialic acid. The spike is essential for both host specificity and viral infectivity. The term 'peplomer' is typically used to refer to a grouping of heterologous proteins on the virus surface that function together. The spike (S) glycoprotein of coronaviruses is known to be essential in the binding of the virus to the host cell at the advent of the infection process. It's been reported that 2019-nCoV can infect the human respiratory epithelial cells through interaction with the human ACE2 receptor. The spike protein is a large type I transmembrane protein containing two subunits, S1 and S2. S1 mainly contains a receptor binding domain (RBD), which is responsible for recognizing the cell surface receptor. S2 contains basic elements needed for the membrane fusion.The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity. The main functions for the Spike protein are summarized as: Mediate receptor binding and membrane fusion; Defines the range of the hosts and specificity of the virus; Main component to bind with the neutralizing antibody; Key target for vaccine design; Can be transmitted between different hosts through gene recombination or mutation of the receptor binding domain (RBD), leading to a higher mortality rate.

General Information

Application ELISA
Host Rabbit
Clonality Monoclonal
Conjugate Non-conjugated
Isotype Rabbit IgG
Immunogen Recombinant SARS-CoV-2 Spike S1 Protein
Assay principle ELISA: 1:5000-1:10000
Purity Protein A
Formula 0.2 μm filtered solution in PBS
Storage instruction This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative- Free.

相關商品

最近瀏覽產品

gotop link
客製化服務 產品 聯絡我們
0