Chemical, Inhibitor

RXDX-106 (CEP-40783)

  • Catalog Number : C5057
  • Number : C5057
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Introduction

RXDX-106 (CEP-40783) is an orally-available, potent and selective TAM(TYRO3, AXL, MER)/MET inhibitor displaying low nanomolar biochemical activity and slow (T1/2 >120 min) inhibitor off-rate in peptide phosphorylation assays and in vitro kinase binding assays, respectively.

General Information

Cas No. 1437321-24-8
Purity ≥ 99%
Molecular Weight 588.56
Formula C31H26F2N4O6
Solubility DMSO 10 mg/mL (16.99 mM) | Ethanol 2 mg/mL (3.40 mM) | Water Insoluble
Storage instruction -20°C powder | -80°C in solvent

Target

Value

Cell Line

Axl

IC50:7 nM 

Cell-free assay

c-Met

IC50:12 nM 

Cell-free assay

Tyro3

IC50:19 nM 

Cell-free assay

MER

IC50:29 nM 

Cell-free assay

Tyro3

IC50:29 nM 

Cell-free assay

VEGFR2

IC50:960 nM 

Cell-free assay

 

Chemical Structure

Chemical Structure| 1437321-24-8

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