Chemical

L-Chicoric Acid

  • Catalog Number : C3246
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Introduction

L-Chicoric Acid ((-)-Chicoric acid) is a dicaffeoyltartaric acid and a potent, selective and reversible HIV-1 integrase inhibitor with an IC50 of ~100 nM. L-Chicoric Acid inhibits HIV-1 replication in tissue culture[1][2][3].

General Information

Cas No. 70831-56-0
Purity > 98%
Molecular Weight 474.37
Formula C22H18O12
Solubility DMSO : 100 mg/mL
Storage instruction -20°C for 1 years │ -80°C for 6 months in solvent

SOLUBILITY

In vitro

DMSO : 100 mg/mL

Preparing

Stock Solutions

concentration

Mass

1 mg

5 mg

10 mg

1 mM

2.1081 mL

10.5403 mL

21.0806 mL

5 mM

0.4216 mL

2.1081 mL

4.2161 mL

10 mM

0.2108 mL

1.0540 mL

2.1081 mL

 

In vivo

1.     Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.5 mg/mL (5.27 mM); Clear solution

2.     Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.5 mg/mL (5.27 mM); Clear solution

3.     Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2.5 mg/mL (5.27 mM); Clear solution

*All of the co-solvents are provided by MCE.

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