Chemical, Inhibitor

Tipifarnib

  • Catalog Number : C4099
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Introduction

Tipifarnib (IND 58359; R115777) is a potent and specific farnesyltransferase inhibitor with an IC50 of 0.6 nM. Tipifarnib is a nonpeptidomimetic quinolinone with potential antineoplastic activity. Tipifarnib (Zarnestra; IND 58359; R115777) binds to and inhibits the enzyme farnesyl protein transferase, an enzyme involved in protein processing (farnesylation) for signal transduction. By inhibiting the farnesylation of proteins, it prevents the activation of Ras oncogenes, inhibits cell growth, induces apoptosis, and inhibits angiogenesis.

General Information

Cas No. 192185-72-1
Purity > 98%
Molecular Weight 489.4
Formula C27H22Cl2N4O
Solubility DMSO:48.94 mg/mL│ethanol;9.79 mg/mL
Storage instruction 2 years -20°C Powder │ 2 weeks 4°C in DMSO │ 6 months -80°C in DMSO
Alias Zarnestra; IND 58359; R115777; IND-58359; IND58359; R-115777; R 115777

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