Chemical, Antibiotics

Polymyxin B sulfate

  • Catalog Number : AN0015
  • Number : AN0015-1g
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Introduction

Polymyxin B is one of the most important antibiotics used to treat gram-negative bacterial infections, including infections caused by carbapenem-resistant non-fermenters and carbapenem-resistant Enterobacteriaceae. Mode of Action: Polymyxin B Sulfate binds to the lipid A portion of bacterial lipopolysaccharides?, disrupting the cytoplasmic membrane by inducing pores large enough to permit nucleotide leakage in bacterial walls. This disrupts the permeability of the cytoplasmic membrane.

General Information

Cas No. 1405-20-5
Molecular Weight 1385.61
Formula C55H96N16O13·2H2SO4
Solubility Soluble in water at 50mg/ml/n
Storage instruction Store at 2-8℃ and protect from light
Grade 

USP Grade

Titer 

≥6000u/mg

Appearance 

white or yellow Powder

pH 

5.0~7.0

Specific rotation 

-78~-90º

 

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