Antibody, IVD Antibody

Claudin 4 (PT1925) mouse mAb

  • Catalog Number : A130230
  • Number :
  • Size:
    Qty :
  • Price : 詢價
  • Stock :
  • print

Introduction

Specificity:
This antibody detects endogenous levels of human Claudin 4. Heat-induced epitope retrieval (HIER) TRIS-EDTA of pH8.0 was highly recommended as antigen repair method in paraffin section.

Background:
claudin 4(CLDN4) Homo sapiens The protein encoded by this intronless gene belongs to the claudin family. Claudins are integral membrane proteins that are components of the epithelial cell tight junctions, which regulate movement of solutes and ions through the paracellular space. This protein is a high-affinity receptor for Clostridium perfringens enterotoxin (CPE) and may play a role in internal organ development and function during pre- and postnatal life. This gene is deleted in Williams-Beuren syndrome, a neurodevelopmental disorder affecting multiple systems. [provided by RefSeq, Sep 2013],

Function:
Disease: Haploinsufficiency of CLDN4 may be the cause of certain cardiovascular and musculo-skeletal abnormalities observed in Williams-Beuren syndrome (WBS), a rare developmental disorder. It is a contiguous gene deletion syndrome involving genes from chromosome band 7q11.23.,
Function: Plays a major role in tight junction-specific obliteration of the intercellular space.,
Similarity: Belongs to the claudin family.,
Subunit: Directly interacts with TJP1/ZO-1, TJP2/ZO-2 and TJP3/ZO-3.,

Subcellular Location:Membranous

General Information

Reactivity Human
Application WB, IHC
Host Mouse
Clonality Monoclonal
Conjugate Non-conjugated
Uniprot O14493
Isotype IgG2b, Kappa
Immunogen Synthesized peptide derived from human Claudin 4
Assay principle IHC-p 1:100-500,WB 1:500-2000
Sample type paraffin section
Purity The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
Expression region Colon,Fetal brain,Trachea,
Storage buffer Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Storage instruction -20°C/1 year
Research topic cell adhesion, pathogenesis, cell-cell adhesion, calcium-independent cell-cell adhesion, biological adhesion,
Alias CLDN4 CPER CPETR1 WBSCR8

最近瀏覽產品

gotop link
客製化服務 產品 聯絡我們
0