Antibody, IVD Antibody

Growth Hormone(GH) (ABT-GH) mouse mAb

  • Catalog Number : A130245
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Introduction

Specificity:This antibody detects endogenous levels of human Growth Hormone(GH). Heat-induced epitope retrieval (HIER) TRIS-EDTA of pH8.0 was highly recommended as antigen repair method in paraffin section.

Background:growth hormone 1(GH1) Homo sapiens The protein encoded by this gene is a member of the somatotropin/prolactin family of hormones which play an important role in growth control. The gene, along with four other related genes, is located at the growth hormone locus on chromosome 17 where they are interspersed in the same transcriptional orientation; an arrangement which is thought to have evolved by a series of gene duplications. The five genes share a remarkably high degree of sequence identity. Alternative splicing generates additional isoforms of each of the five growth hormones, leading to further diversity and potential for specialization. This particular family member is expressed in the pituitary but not in placental tissue as is the case for the other four genes in the growth hormone locus. Mutations in or deletions of the gene lead to growth hormone deficiency and short stature. [provided by RefSeq, Jul 2008]

Function:
Disease: Defects in GH1 are a cause of isolated growth hormone deficiency type IB (IGHD IB) [MIM:262400]; also known as pituitary dwarfism I. IGHD IB is an autosomal recessive deficiency of GH which causes short stature.
Disease: Defects in GH1 are a cause of isolated growth hormone deficiency type II (IGHD II) [MIM:173100]. IGHD II is an autosomal dominant deficiency of GH which causes short stature.,disease:Defects in GH1 are the cause of Kowarski syndrome [MIM:262650]; also known as pituitary dwarfism VI.,
Disease: Defects in GH1 may be a cause of short stature [MIM:604271]. Short stature is defined by a subnormal rate of growth.
Function: Plays an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1.

Subcellular Location:Cytoplasmic

General Information

Reactivity Human
Application IHC
Host Mouse
Clonality Monoclonal
Conjugate Non-conjugated
Uniprot P01241
Isotype IgG
Immunogen Synthesized peptide derived from human Growth Hormone(GH)
Assay principle IHC-p 1:100-500
Sample type paraffin section
Purity The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
Expression region Pituitary
Storage buffer Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Storage instruction -20°C/1 year
Research topic regulation of protein amino acid phosphorylation, positive regulation of protein amino acid phosphorylation, cell surface receptor linked signal transduction, enzyme linked receptor protein signaling pathway, transmembrane receptor protein tyrosine kinase signaling pathway, intracellular signaling cascade, protein kinase cascade, JAK-STAT cascade, carbohydrate transport, hexose transport, response to endogenous stimulus, response to hormone stimulus, positive regulation of signal transduction, response to o
Alias GH1

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