SOX2 recombinant protein
- Catalog Number : AD3104
- Number : AD3104
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General Information
| Reactivity | Human | ||||||
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| Purity | >90% as determined by SDS-PAGE | ||||||
| Storage buffer | Phosphate-buffered solution | ||||||
| Storage instruction | -15°C to -25°C/1 year(Avoid freeze / thaw cycles) | ||||||
| Alias | SOX2
Transcription factor SOX-2 |
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| Source | Mammalian cells | ||||||
| Sequence | Amino acid:151-251,with rabbit FC tag. | ||||||
| Gene Name | SOX2 | ||||||
| Protein Name | Transcription factor SOX-2 | ||||||
| Database Link |
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| Background | SRY-box 2(SOX2) Homo sapiens This intronless gene encodes a member of the SRY-related HMG-box (SOX) family of transcription factors involved in the regulation of embryonic development and in the determination of cell fate. The product of this gene is required for stem-cell maintenance in the central nervous system, and also regulates gene expression in the stomach. Mutations in this gene have been associated with optic nerve hypoplasia and with syndromic microphthalmia, a severe form of structural eye malformation. This gene lies within an intron of another gene called SOX2 overlapping transcript (SOX2OT). [provided by RefSeq, Jul 2008]. | ||||||
| Function | Disease:Defects in SOX2 are the cause of microphthalmia syndromic type 3 (MCOPS3) [MIM:206900]. Microphthalmia is a clinically heterogeneous disorder of eye formation, ranging from small size of a single eye to complete bilateral absence of ocular tissues (anophthalmia). In many cases, microphthalmia/anophthalmia occurs in association with syndromes that include non-ocular abnormalities. MCOPS3 is characterized by the rare association of malformations including uni- or bilateral anophthalmia or microphthalmia, and esophageal atresia with trachoesophageal fistula.,Function:Transcription factor that forms a trimeric complex with OCT4 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206. Critical for early embryogenesis and for embryonic stem cell pluripotency.,online information:Sox2 entry,PTM:Sumoylation inhibits binding on DNA and negatively regulates the FGF4 transactivation.,similarity:Contains 1 HMG box DNA-binding domain. | ||||||
| Cellular Localization | Nuclear | ||||||
| Tissue Expression | Fetal brain,Lung,Retina. |
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