c-MYC (PTR2340) Mouse mAb

IHC 1:200-1000; WB 1:500-2000; IF 1:100-500; ELISA 1:1000-5000

This antibody detects endogenous levels of c-MYC protein.

Protein G

MYC BHLHE39

Myc proto-oncogene protein (Class E basic helix-loop-helix protein 39) (bHLHe39) (Proto-oncogene c-Myc) (Transcription factor p64)

v-myc avian myelocytomatosis viral oncogene homolog(MYC) Homo sapiens The protein encoded by this gene is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of this gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma. There is evidence to show that alternative translation initiations from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site result in the production of two isoforms with distinct N-termini. The synthesis of non-AUG initiated protein is suppressed in Burkitt's lymphomas, suggesting its importance in the normal function of this gene. [provided by RefSeq, Jul 2008].

Disease:A chromosomal aberration involving MYC may be a cause of a form of B-cell chronic lymphocytic leukemia. Translocation t(8;12)(q24;q22) with BTG1.,Disease:Overexpression of MYC is implicated in the etiology of a variety of hematopoietic tumors.,Function:Participates in the regulation of gene transcription. Binds DNA both in a non-specific manner and also specifically to recognizes the core sequence 5'-CAC[GA]TG-3'. Seems to activate the transcription of growth-related genes.,online information:Myc entry,PTM:Phosphorylated by PRKDC.,similarity:Contains 1 basic helix-loop-helix (bHLH) domain.,subunit:Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as a heterodimer with MAX. Interacts with TAF1C and SPAG9. Interacts with PARP10. Interacts with KDM5A and KDM5B.

Nuclear

Whole cell lysates of MDCK were separated by 12% SDS-PAGE, and the membrane was blotted with anti-C-Myc(PTR2340) antibody. The HRP-conjugated Goat anti-Mouse IgG(H + L) antibody was used to detect the antibody. Lane 1: MDCK

Whole cell lysates of NIH-3T3 were separated by 12% SDS-PAGE, and the membrane was blotted with anti-C-Myc(PTR2340) antibody. The HRP-conjugated Goat anti-Mouse IgG(H + L) antibody was used to detect the antibody. Lane 1: NIH-3T3

Whole cell lysates of A549 were separated by 12% SDS-PAGE, and the membrane was blotted with anti-C-Myc antibody. The HRP-conjugated Goat anti-Mouse IgG(H + L) antibody was used to detect the antibody. Lane 1: A549

Human prostate tissue was stained with Anti-c-MYC (PTR2340) Antibody

Human skin tissue was stained with Anti-c-MYC (PTR2340) Antibody

Human tonsil tissue was stained with Anti-c-MYC (PTR2340) Antibody