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Name 14-3-3 Family Antibody Sampler Kit
Catalog# AK0101
Type Antibody Sampler Kit
Reactivity Hu, Ms, Rt
Application WB, IF, ELISA, IHC
Host Rb
Clonality Polyclonal
Conjugate HRP,Non-conjugated
Description The 14-3-3 family of proteins plays a key regulatory role in signal transduction, checkpoint control, apoptotic and nutrient-sensing pathways . 14-3-3 proteins are highly conserved and ubiquitously expressed. There are at least seven isoforms, β, γ, ε, σ, ζ, τ, and η that have been identified in mammals. The initially described α and δ isoforms are confirmed to be phosphorylated forms of β and ζ, respectively. Through their amino-terminal α helical region, 14-3-3 proteins form homo- or heterodimers that interact with a wide variety of proteins: transcription factors, metabolic enzymes, cytoskeletal proteins, kinases, phosphatases, and other signaling molecules. The interaction of 14-3-3 proteins with their targets is primarily through a phospho-Ser/Thr motif. However, binding to divergent phospho-Ser/Thr motifs, as well as phosphorylation independent interactions has been observed. 14-3-3 binding masks specific sequences of the target protein, and therefore, modulates target protein localization, phosphorylation state, stability, and molecular interactions. 14-3-3 proteins may also induce target protein conformational changes that modify target protein function. Distinct temporal and spatial expression patterns of 14-3-3 isoforms have been observed in development and in acute response to extracellular signals and drugs, suggesting that 14-3-3 isoforms may perform different functions despite their sequence similarities. Several studies suggest that 14-3-3 isoforms are differentially regulated in cancer and neurological syndromes.
Storage instruction Store at -20℃. Avoid freeze / thaw cycles.
Research topic 14-3-3 protein family

Product Includes

Product name Quantity  Applications Reactivity Host
14-3-3 beta/alpha Polyclonal Antibody 20μL WB, IHC, IF, ELISA Human, Mouse, Rat Rabbit
14-3-3 epsilon Polyclonal Antibody 20μL WB, IHC, IF, ELISA Human, Mouse, Rat Rabbit
14-3-3 zeta/delta Polyclonal Antibody 20μL WB, IHC, IF, IP, ELISA Human, Mouse, Rat Rabbit
14-3-3 theta Polyclonal Antibody 20μL WB, IHC, IF, ELISA Human, Mouse, Rat Rabbit
14-3-3 theta Polyclonal Antibody 20μL WB, IHC, IF, ELISA Human, Mouse, Rat Rabbit
Goat Anti-Rabbit IgG (H+L)(peroxidase/HRP conjugated) 120μL WB,ELISA    
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AK0101

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5*20μLRequest
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