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B Cell Signaling Antibody Sampler Kit

Catalog# AK0128
Type Antibody Sampler Kit
Reactivity Hu, Ms, Rt
Application WB, ELISA
Host Rb
Clonality Polyclonal
Conjugate HRP,Non-conjugated
Description Antigen receptors found on the surface of B cells contain a heterodimeric signaling component composed of CD79A and CD79B, also known as Ig α and Ig ß, respectively. Presence of this receptor complex is essential for B-cell development and function. Antigen binding precedes formation of the CD79A and CD79B heterodimer and subsequent activation of receptor associated kinases. Tyr182 of mouse CD79A (corresponding to Tyr188 of human CD79A) is one of two key tyrosine residues in the immunoreceptor tyrosine-based activation motif (ITAM) of CD79A that are phosphorylated by Src family kinases, and play a critical role in modulating signal transduction following immune receptor activation. Syk is a protein tyrosine kinase that plays an important role in intracellular signal transduction in hematopoietic cells. Syk interacts with immunoreceptor tyrosine-based activation motifs (ITAMs) located in the cytoplasmic domains of immune receptors. It couples the activated immunoreceptors to downstream signaling events that mediate diverse cellular responses, including proliferation, differentiation, and phagocytosis. There is also evidence that Syk plays a role in nonimmune cells; Syk is a potential tumor suppressor in human breast carcinomas. Tyrosine 525 and 526 are located in the activation loop of the Syk kinase domain, and phosphorylation of Tyr525/526 of human Syk (equivalent to the Tyr519/520 of mouse Syk) is essential for Syk function. Lyn, one of the Src family members, is predominantly expressed in hematopoietic cells. Two tyrosine residues have been reported to play a crucial role in the regulation of protein tyrosine kinases of the Src family. Autophosphorylation of Tyr396 (equivalent to Tyr416 of Src), located in the catalytic domain, correlates with enzyme activation. Csk-mediated phosphorylation of the carboxy-terminal Tyr507 (equivalent to Tyr527 of Src) inactivates the kinase. Tyrosine phosphorylation and activation of Lyn occurs upon association with cell surface receptors such as the B cell Ag receptor (BCR) an
Storage instruction Store at -20℃. Avoid freeze / thaw cycles.
Research topic B Cell Signaling; Immunology

Product Includes

Product name Quantity  Applications Reactivity Host
Phospho-c-SRC (Tyr419) Polyclonal Antibody 20μL WB,IHC,ELISA Human, Mouse, Rat Rabbit
Phospho-SYK (Tyr525) Polyclonal Antibody 20μL WB,IHC,ELISA Human, Mouse, Rat, Monkey Rabbit
Phospho-BTK (Tyr223) Polyclonal Antibody 20μL WB,ELISA Human, Mouse, Rat Rabbit
Phospho-PLCG2 (Tyr753) Polyclonal Antibody 20μL WB,IHC,ELISA Human, Mouse, Rat Rabbit
Phospho-BLNK (Tyr96) Polyclonal Antibody 20μL WB,IHC,ELISA Human, Mouse, Monkey Rabbit
CD79A Polyclonal Antibody 20μL WB,ELISA Human, Mouse Rabbit
Goat Anti-Rabbit IgG (H+L)(peroxidase/HRP conjugated) 120μL WB,ELISA    
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