Antibody, Antibody Sampler Kit
Autophagy Atg8 Family Antibody Sampler Kit
- Catalog Number : AK0126
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Introduction
Autophagy is a catabolic process for the autophagosomic-lysosomal degradation of bulk cytoplasmic contents. Autophagy is generally activated by conditions of nutrient deprivation, but it has also been associated with a number of physiological processes, including development, differentiation, neurodegenerative diseases, infection, and cancer. Atg8 is a ubiquitin-like protein that is critical for autophagosome formation. Atg8 is synthesized as a precursor protein that is processed by the cysteine protease Atg4, followed by lipidation with phosphatidylethanolamine (PE) in a ubiqutin-like conjugation pathway involving Atg7 and Atg3. This processing of Atg8, which is described as a conversion from type-I to type-II forms, is frequently described as a marker for autophagy. The type-II form of Atg8 is incorporated into maturing autophagosomes and leads to the recruitment of additional autophagy components, including cargo receptors like SQSTM1/p62. While yeast has a single Atg8 gene, many eukaryotes have at least six orthologs, including three microtubule-associated protein 1 light chain 3 (MAP1LC3/LC3) family members (LC3A, LC3B, and LC3C) and three GABAA receptor associated protein (GABARAP) family members (GABARAP, GABARAPL1/GEC1, and GABARAPL2/GATE-16). While highly conserved, these various family members can have important differences in their post-translational processing, expression profile, and protein interactions including distinct cargo receptor. This complexity within the Atg8 family is critical for selective mechanisms of autophagy that have been reported.
General Information
| Reactivity | Human |
|---|---|
| Application | WB, ELISA |
| Host | Mouse, Rabbit |
| Clonality | Monoclonal,Polyclonal |
| Conjugate | HRP,Non-conjugated |
| Storage instruction | Store at -20℃. Avoid freeze / thaw cycles. |
| Research topic | Autophagy |
Product Includes
| Product name | Quantity | Applications | Reactivity | Host |
| MAP1LC3A Monoclonal Antibody | 20μL | WB,IHC-p,IF | Human, Mouse, Rat | Mouse |
| MAP1LC3B Polyclonal Antibody | 20μL | WB,IHC-p,IF | Human, Mouse, Rat | Rabbit |
| MAP1LC3C Polyclonal Antibody | 20μL | WB,ELISA | Human | Rabbit |
| Goat Anti-Rabbit IgG (H+L)(peroxidase/HRP conjugated) | 120μL | WB,ELISA | ||
| Goat Anti-Mouse IgG(H+L)(peroxidase/HRP conjugated) | 120μL | WB,ELISA |
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